摘要
先以聚乙二醇(PEG)为中心嵌段,经消旋丙交酯(D,LLA)开环扩链,进而用丙烯酸酯封端制备了可生物降解交联剂。然后以辛酸亚锡为催化剂、甲基丙烯酸羟乙酯(HEMA)为共引发剂引发D,LLA开环聚合,制备了末端双键功能化的大分子单体(PLAHEMA)。最后以可降解交联剂、大分子单体和N乙烯基吡咯烷酮(NVP)为原料,采用自由基聚合方法合成了新型可生物降解两亲性交联共聚物,并对其亲水性和力学性能进行了研究。
Firstly, biodegradable crosslinking agent having a poly(ethylene glycol)(PEG) central block, extended with poly(D,L-lactide) and terminated with diacrylate, was prepared. Then, PLA-HEMA macromonomer(MC) with the functional end double bond was synthesized by bulk ring-opening polymerization of D,L-lactide(D,L-LA) using stannous 2-ethyl hexanoate(Sn(Oct)_2) as a catalyst, and 2-hydroxyethyl methacrylate(HEMA) as a co-initiator. Lastly, the novel biodegradable crosslinked copolymers were synthesized by the free radical polymerization from biodegradable crosslinking agent, macromonomer and N-vinyl pyrrolidone (NVP), the hydrophilicity and mechanical properties of the copolymers were also studied.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2005年第2期299-304,共6页
Journal of Functional Polymers
基金
国家自然科学基金(30170272)
广东省自然科学基金博士科研启动基金(04300673)
暨南大学自然科学基金资助项目(51204007)
