摘要
目的研究国产新型血管紧张素II受体拮抗剂伊贝沙坦对原发性高血压患者血管内皮功能的影响。方法应用2-D多普勒超声心动图观察30例原发性高血压患者口服伊贝沙坦(每日150～300mg)治疗16周前后内皮依赖性舒血管功能的变化。结果肱动脉加压前后(流量介导的血管舒张,反映内皮依赖性舒血管功能)的血管内径变化百分比在治疗后明显增加;而含服硝酸甘油前后(硝酸甘油介导的血管舒张,反映非内皮依赖性舒血管功能)肱动脉内径变化百分比在治疗后无明显变化。结论伊贝沙坦可以改善内皮依赖性舒血管功能。
Objective To observe the effect of Irbesartan, a new angiotensin 11 receptor antagonist, on endothelial function in essential hypertensive patients. Methods The endothelial一dependent vasodilation function were, observed in 30 essential hypertensive patients by2D一Doppler echocardiography before and after 16一week treatment with Irbesantan(150一300mg cnce daily). Results After treated with Irbesanan for 16 weeks, difference in response to nitroglycerin(nitroglycerin一mediated vasodilation,reflected non endothelial-dependent vasodilation function). Conclusions Irbesartan can improve endothelial function.
出处
《海南医学》
CAS
2005年第7期14-15,共2页
Hainan Medical Journal
关键词
高血压
血管内皮
超声心动图
Irbesartan
hypertension
endothelium,vascular
echocardiography
