摘要
目的比较靶控输注与手控输注异丙酚用于人工流产手术的麻醉。方法选择60例自愿接受无痛人工流产的患者随机分为两组:A组静注异丙酚2mg/kg,B组异丙酚靶控输注,术中连续监测平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(SpO2)、脑电双频指数(BIS)。记录异丙酚总量(mg)、诱导时间(s)、苏醒时间(s),并观察麻醉期间不良反应及并发症,包括局部注射痛、呼吸抑制(SpO2<90%)、术中体动、苏醒延迟。结果①两组患者诱导时间、异丙酚总量统计学上无显著性差异,苏醒时间B组明显短于A组;②A组诱导后MAP较术前下降了15.16%,SpO2下降了2.77%,B组诱导后MAP较术前仅下降了13.49%,SpO2下降了1.30%;③A组有3例病人在麻醉开始时出现轻微静脉注射部位疼痛;4例在扩张宫颈时出现短暂肢体活动,追加异丙酚后很快消失,B组静脉注射部位疼痛和术中体动。所有病人未发生呼吸抑制及苏醒延迟、术中及术后无药物过敏及恶心呕吐。结论在未使用术前药的情况下,以血浆药物浓度6μg/ml靶控输注应用于人工流产手术麻醉,可使麻醉诱导及维持过程平稳,术中病人血流动力学稳定,术后恢复迅速而且无恶心、呕吐等并发症。所以这种麻醉方法更适用于门诊人工流产手术。
Objective To compare the effect of target-controlled infusion (TCI)with manually controlled infusion(MCI) of propofol used for induced abortion operation. Methods Sixty patients were randomly assigned to 2 groups: group A was given iv propofol 2 mg/kg. Group B was anesthetized by TCI of propofol, and the blood target concentration of propofol was set at 6 μg/ml during anesthesia. Results ① There was no significant difference in total dose of propofol and in induction time between both groups. But the wakening time was significantly shorter in group B than in group A(P<0.05). ②In group A, mean artery pressure (MAP) significantly decreased by 15.16% and SpO2 by 2.77% ;while in group B heart rate(HR) was a slightly decreased by 13.49% and SpO2 by 1.30%. ③In group A, three patients felt a slight pain in injection part and 4 patients showed transient limb activity at extending cervix. All the patients did not take place respiration inhibition, wakening delay, nausea and vomiting. Conclusion Hemodynamics are relatively stable during anesthesia induction and maintenance period when TCI propofol is used for induced abortion , and patients wake up soon after operation. So TCI of propofol is suitable for induced abortion operation.
出处
《山西医科大学学报》
CAS
2005年第3期354-356,共3页
Journal of Shanxi Medical University
关键词
输注
静脉内
二异丙酚
麻醉
流产
人工
infusions, intravenous
propofol
anesthesia
abortion, induced
