摘要
目的探讨幽门螺杆菌感染与胃黏膜淋巴滤泡发生的关系,以及诱导胃黏膜上皮细胞表达人类白细胞DR抗原的可能机制。方法观察164例幽门螺杆菌阳性与96例幽门螺杆菌阴性胃黏膜淋巴滤泡的发生率;应用卵白素生物素过氧化酶法检测幽门螺杆菌阳性和幽门螺杆菌阴性胃黏膜淋巴滤泡周围上皮细胞人类白细胞DR抗原的表达并进行相关分析。结果幽门螺杆菌阳性组胃黏膜淋巴滤泡的发生率(90/164)显著高于幽门螺杆菌阴性组(16/96)(P<0.001),而幽门螺杆菌阳性组与幽门螺杆菌阴性组胃黏膜淋巴滤泡周围上皮细胞人类白细胞DR抗原的表达无显著性差异(P>0.05)。结论幽门螺杆菌促使胃黏膜上皮细胞表达人类白细胞DR抗原,可能是通过促使局部胃黏膜炎症的形成,进而诱导胃上皮细胞表达人类白细胞DR抗原。
Objective To invertigate the relationship between Helicobacter pylori infection and lymph follicle development and the possible mechanism of HLA-DR antigen expression on gastric epithelium induced by H.Pylori. Methods By using ABC immunoperoxidase staining method with the help of anti-human leucocyte antigen HLA-DR antibody, we studied HLA-DR antigen expression on gastric epithelium around the lymph follicles in H.Pylori infected and uninfected samples. Results The frequency of lymph follicle in H.pylori-positive specimens (90/164) was significantly higher than that in H.pylori-negative specimens (16/96) (P<0.001). There was no difference of HLA-DR expression on the epithelium around the lymph follicles between H.pylori-positive specimens and H.pylori-negative specimens (P>0.05). Conclusion The results suggest that H.pylori infection may trigger cell infiltration and then induce the HLA-DR antigen expression on gastric epithelium.
出处
《海军总医院学报》
2005年第2期69-72,共4页
Journal of Naval General Hospital of PLA
