摘要
目的探讨β-catenin在上尿路移行细胞癌中表达的临床意义。方法免疫组化法检测βcatenin和磷酸化β-catenin在38例上尿路移行细胞癌中的表达情况,并分析其与预后的关系;Westernblot法检测β-catenin在26例上尿路移行细胞癌中的表达情况。结果磷酸化的β-catenin在所有标本中均为阴性表达。β-catenin随着病理分级的增高正常表达率下降(P<0.05),随着临床分期的增高,正常表达率下降(P<0.05);β-catenin异常表达方式为下调表达,没有在细胞内的分布异常;β-catenin异常表达组预后不良。结论上尿路移行细胞癌中存在βcatenin的异常表达,异常表达与预后不良有关,可作为判断预后的指标。
Objective To investigate the expressionofβ-cateninand its clinical significance in transitional cell carcinoma of the upper urinary tract. Methods Immunohistochemistry was employed to investigate the expressionsof β-cateninand phospho-β-cateninin 38 cases of transitional cell carcinoma of the upper urinary tract. Another 26 cases were investigated by Western blot. We analyzed the relation between the expressionsand the prognosis. Results All the cases were phospho-β-cateninnegative. The normal expression rate of β-catenindecreased with the increasein pathological grades andclinical stages (P<0.05). There were no abnormal distribution ofβ-catenin. Patients withabnormal expressionsof β-catenin hadpoor prognosis. Conclusion The abnormal expressionof β-cateninin transitional cell carcinoma of the upper urinary tract suggests poor prognosis.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2005年第3期318-321,共4页
Chinese Journal of Histochemistry and Cytochemistry
