摘要
目的分析虎杖水提液对非酒精性脂肪肝大鼠进行干预的效果。方法以高脂饲料饲养Wistar大鼠12周,诱发NAFLD,然后转以基础饲料饲养4周,并对NAFLD大鼠进行虎杖水提液干预与对照实验。通过生化检测方法分析各组大鼠血清和肝组织甘油三酯、总胆固醇和葡萄糖水平的变化。结果干预组大鼠的肝组织和血清的甘油三酯、总胆固醇和葡萄糖含量均低于对照组,其中肝、血总胆固醇和血清甘油三酯含量的差异显著(P<0.05)。结论虎杖水提液能够调整和改善NAFLD大鼠的脂肪和糖代谢,降低肝组织和血清甘油三酯、总胆固醇和葡萄糖水平。
Objective To detect the effect of non-alcohol fatty liver disease rats in the intervention of rizoma polygoni cuspidati. Methods The Wistar rats were f ed with high fatty chow for 12 weeks to induce NAFLD.And then,these NAFLD rats w ere fed with the low fatty chow and intervene d by the extracts of rizoma polygoni cus pidati or controlled by distilled water for 4 weeks.The contents of liver and serum triglycerde,total cholesterol,and gluco se were detected by the biochemical meth ods. Results Comparing the control group, it decreased that the contents of liver and serum triglycerde,total cholesterol, and glucose in intervention group.The di fferences of liver and serum total chole sterol,and serum triglycerde between the se two groups were significant (P<0.05). Conclusion The extracts of rizoma polygo ni cuspidati can improve the adipose and glucose metabolism of NAFLD rats.It can decrease the contents of triglycerde,to tal cholesterol,and glucose in liver and serum.
出处
《广州医药》
2005年第3期57-59,共3页
Guangzhou Medical Journal
