摘要
本文采用层析荧光法检测肺癌患者血清肌酸激酶（ＣＫ）及其ＢＢ型同工酶（ＣＫ－ＢＢ）的活性，并开探讨ＣＫ－ＢＢ与肺癌细胞类型及病变严重程度间的关系。结果表明，肺癌患者血清ＣＫ－ＢＢ活性升高阳性率为３９％，显著高于对照组。其中小细胞肺癌阳性率为６２％，非小细胞肺癌为２８％。两者ＣＫ－ＢＢ活性差异有非常显著性。血清ＣＫ－ＢＢ活性与病变严重程度呈正相关。
The activity of creatine kinase(CK) and its BB isoenzyme(CK-BB)was measured in 38 cases with untreated lung cancer, 29 cases of benign pulmonary diseases, and 33 healthy persons. The results showed that: 1. The serum CK-BB was significantly higher in lung cancer group in compare with benign group or healthy persons (P<0.05).2. Serum CK-BB activity in patients with small cell lung cancer(SCLC) were higher than non-small cell lung cancer (NSCLC) (P<0-005).3.The raising of CK-BB in Ⅰ,Ⅱ,Ⅲa stages was lower than Ⅲ b,Ⅳ stages(P<0.05).Higher levels were present(57%) in Ⅲb,Ⅳ stages. It is suggested that the evaluation of serum CK-BB might indicate the stage of disease or the prognosis of lung cancer.
出处
《肿瘤》
CAS
CSCD
北大核心
1994年第6期311-313,共3页
Tumor
