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P物质受体在体外培养破骨细胞内的表达及意义 被引量：3

Expression of Neurokinin-1 receptor in osteoclasts
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摘要 目的观察P物质受体(NK1)在体外培养大鼠破骨细胞内的表达情况。方法采用细胞培养和免疫组化ABC方法,检测NK1受体在大鼠破骨细胞内的表达。结果NK1受体在大鼠破骨细胞内均呈阳性表达,胞质着色。结论P物质可能直接作用于破骨细胞,并在正畸牙槽骨改建中发挥作用。 Objective To investigate the expression of Neurokinin-1 receptor in osteoclasts. Methods Neurokinin-1 receptor expression in osteoclasts was detected by cell culture and immunohistochemical method. Results Immunoreactivity for Neurokinin-1 receptor was distributed in the cytoplasm of osteoclasts. Conclusion The findings further support the hypothesis that substance P may have regulatory effects on osteoclasts directly.
作者 孙应明 罗颂椒 赵昱辉
机构地区 四川大学华西口腔医学院正畸科 第四军医大学口腔医学院正畸科
出处 《口腔医学》 CAS 2005年第3期169-171,共3页 Stomatology
基金 国家自然科学基金资助项目(30200320)
关键词 NK1受体 P物质 破骨细胞 Neurokinin-1 receptor substance P osteoclasts
分类号 R394.26 [医药卫生—医学遗传学]
  • 相关文献

参考文献12

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二级参考文献15

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共引文献14

同被引文献17

  • 1孙应明,段银钟,樊成涛.P物质对体外培养成骨细胞内游离钙浓度的影响[J].中华口腔医学杂志,2001,36(6):11-13. 被引量：6
  • 2侯玉,段银钟,孙应明.P物质对体外培养成骨细胞增殖和活性的影响[J].第四军医大学学报,2006,27(3):202-204. 被引量：5
  • 3孙应明,罗颂椒.免疫荧光法观察P物质神经纤维在大鼠牙髓及牙周组织中的分布[J].中国美容医学,2006,15(7):780-781. 被引量：5
  • 4赵景民,翟为溶,张月娥,朱虹光,庄丽,汤钊猷.肝细胞癌整合蛋白α5β1、纤维连接蛋白及其降解片段的表达[J].中华病理学杂志,1997,26(2):65-69. 被引量：27
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引证文献3

二级引证文献8

口腔医学
2005年 第3期

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