摘要
目的探讨与膀胱移行细胞癌预后相关的新诊断方法。方法采用免疫组化SP法,检侧68例原发性膀胱移行细胞癌和10例正常膀胱组织标本环氧化酶-2(COX-2)的表达,结合临床资料,探讨其相互联系以及其表达与预后的关系。结果68例膀胱移行细胞癌组织中COX-2阳性表达率为63.2%(43/68),与病理分级、临床分期、血管浸润有关(P<0.05),而与淋巴结是否转移无显著性差异(P>0.05);对照组10例正常膀胱黏膜COX-2表达均为阴性;COX-2表达阳性生存超过5年者(54.1%)明显低于COX-2表达阴性者(91.3%)(P<0.05)。结论COX-2表达与膀胱移行细胞癌的恶性程度密切相关,检测COX-2表达对判断膀胱移行细胞癌预后有重要意义。
Objective To investigate a new diagnostic method for the prognosis of bladder transitional cell cancer. Methods Expressions of cyclooxygenase-2(COX-2) in 68 cases of primary transitional cell carcinoma (TCC) and 10 cases of normal bladder tissue were assayed with immunohistochemical technique (S-P Method). Their relation to the pathological grading, clinical stages and prognosis were analyzed. Results All normal bladder tissues showed negative staining while the rate of expression of COX-2 in neoplastic tissues was 63.2%(43/68). The positive rates of COX-2 expression in poorly differentiated and invasive bladder tumors were higher than in those well differentiated and superficial tumors (P<0.01,P< 0.001 ); the expression of COX-2 in carcinoma tissue showed positive relationship with tumor vascular invasion ( P<0.05), but no relationship with lymph node metastasis(P>0.05); the 5-year survival rate (54.1%) of patients with positive expression of COX-2 was significantly lower than that(91.3%) of patients with negative expression of COX-2 (P<0.05). Conclusion Expression of COX-2 has important influence on the biological behavior of bladder carcinoma, and expression of COX-2 may aid in predicting the prognosis of bladder transitional cell cancer.
出处
《现代泌尿外科杂志》
CAS
2005年第3期128-130,共3页
Journal of Modern Urology
