摘要
目的观察国产长春瑞滨和顺铂联合化疗后放射治疗中晚期食管癌疗效。方法采用NP方案化疗后放射治疗中晚期食管癌25例,均为初治病人。结果CR3例,PR15例,NC5例,PD2例,总有效率72%。毒性反应为骨髓抑制,白细胞下降为16%,无Ⅲ～Ⅳ度骨髓抑制,局部静脉炎为12%。结论NP方案化疗后放射治疗中晚期食管癌近期疗效高,值得临床推广应用。
Objective To evaluate the result of radiotherapy after combined chemotherapy with Gainuo plus Cisplatin (DDP) in the treatment of esophageal carcinoma.Method 25 patients with mediate and advanced esophageal carcinoma were enrolled in this study. All the patients had no prior treatment.Results Completely response was observed in 3 patients, partial response was observed in 15 patients.Overall response rate was 44%.No change was observed in 5 patients. Progress disease was observed in 2 patients. The dose limiting toxicity was neutropenia but no in grades Ⅲ and Ⅳ. The local venous toxicity was observed in 12% of the patients.Conclusion A high response rate was obtained in mediate and advanced esophageal carcinoma treated by radiotherapy after chemotherapy with Gainuo plus DDP.
出处
《河南肿瘤学杂志》
2005年第3期170-171,共2页
Henan Journal of Oncology
关键词
食管肿瘤
化放联合治疗
盖诺
顺铂
esophageal carcinoma
chemoradiotherapy
Gainuo
Cisplatin
