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B型利钠肽在心力衰竭患者临床评估中的作用 被引量:1

Clinical evaluation effect of brain natriuretic peptide in patients with heart failure
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摘要 目的:研究B型利钠肽(BNP)检测在慢性心力衰竭(CHF)患者的诊断、病情评估等方面的临床价值。方法:选取2004年6月~2005年1月在我院住院的60例CHF患者(CHF组)及同期住院经冠状动脉造影、超声心动图及其他检查证实无器质性心脏病的患者20例(对照组)。采用酶联免疫吸附法(ELISA)测定患者血浆BNP水平,应用美国GE公司VIVED7彩色多普勒超声诊断仪测定相关参数及左室功能。分析BNP水平与患者心功能状态、心脏超声指标的关系。结果:CHF组患者血浆BNP水平为(96.49±85.73)pg/ml,显著高于对照组(5.79±4.22)pg/ml(P<0.001);在纽约心脏病学会(NYHA)心功能分级的不同亚组间血浆BNP水平分别为:(22.40±9.72)、(47.77±20.03)、(88.38±35.87)、(184.69±92.93)pg/ml,差异均具有统计学意义。血浆BNP水平随着NHYA心功能分级的增加而显著升高;与左室射血分数(LVEF)呈显著负相关(r=-0.675,P<0.001),与左室舒张末径(LVEDD)呈显著正相关(r=0.682,P<0.001)。结论:心力衰竭患者血浆BNP水平随着心力衰竭严重程度的增加而升高,并能较好反映左室功能状态,可作为一种简便快速的手段用于CHF的诊断及危险分层。 Objective: To explore the clinical value of plasma brain natriuretic peptide(BNP) on the diagnosis and clinical evaluation on patients with chronic heart failure(CHF). Methods: 60 patients with heart failure and 20 patients without cardiopathy according to the results of coronary artery angiography, echocardiography and other examination were enrolled from June 2004 to Jan 2005. BNP levels were measured by ELISA. Colored Doppler echocardiography was performed to measure the left ventricular function and the correlating parameters. Analyze the correlation between BNP level, the state of cardiac function and the echocardiography markers. Results: BNP level in CHF group was markedly higher than that in control group(96.49±85.73)pg/ml vs(5.79±4.22)pg/ml(P<0.001); in different NYHA functional classes were (22.40±9.72) pg/ml, (47.77±20.03) pg/ml, (88.38±35.87) pg/ml, (184.69±92.93) pg/ml respectively, and there were statistical significance among them.Serum BNP level increased significantly with incremental NYHA functional classes;and had a negative correlation with LVEF(r=-0.675, P<0.001), a positive correlation with LVEDD(r=0.682, P<0.001). Conclusion: Serum BNP level in patients with CHF elevated significantly with the severity of heart failure and can better reflect the left ventricular function. It can be served as a effective marker of the diagnose and risk stratification in CHF.
出处 《新疆医科大学学报》 CAS 2005年第5期434-436,共3页 Journal of Xinjiang Medical University
关键词 B型利钠肽 心力衰竭 诊断 危险分层 brain natriuretic peptide(BNP) heart failure diagnosis risk stratification
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参考文献11

  • 1秦俭,何士大,华琦.心力衰竭临床与脑钠素[J].中国医药导刊,2002,4(5):336-337. 被引量:7
  • 2Yoshimura M, Yasue H, Okumura K, et al. Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure[J]. Circulation,1993,87(2):464-469.
  • 3Levin ER, Gardnetr DG, Samson WK. Natriuretic peptides[J]. N Engl J Med,1998,399:321-328.
  • 4Kruger S, Graf J, Kunz D, et al. Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure[J]. J Am Coll Cardiol,2002,40:718-722.
  • 5Maeda K, Takayoshi T, Wada A, et al. Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction[J]. Am Heart J,1998,135:825-832.
  • 6Hobbs RE. Using BNP to diagnose,manage,and treat failure[J]. Cleve Clin J Med,2003,70(4):333-336.
  • 7Tsutamoto T, Wada A, Maeda K, et al. Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure:prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction[J].Circulation,1997,96(2):388-390.
  • 8Maisel A, Krishnaswamy P, Nowak R, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure[J]. N Engl J Med,2002,347(3):161.
  • 9Clerio A, Lervasi G, Chicca M, et al. Circulating levels of cardiac natriuretic peptides(ANP and BNP)measured by highly sensitive and specific immunoradiometric assays in normal subjects and in patients with different degrees of heart failure[J]. J Endocrinol Invest,1998,27:170-179.
  • 10Maisel A. B-type natriuretic peptide levels:A potential novel "white count" for congestive heart failure[J]. J Cardiac failure,2001,7(2):183.

二级参考文献20

  • 1Yasue H, Yoshimura M, Sumida H, et al. Localization and mechanism of secretiou of B - type natriuretic peptide in comparison with those of A - type natriuretic peptide in normal subjects and patients with heart failure. Circulation, 1994; 90 (1): 195~203
  • 2Hystad ME. Klinge R, Spurkland A, et al. Contrasting cardiac regional responses of A - type and B - type natriuretic peptide to experimental chronic heart failure. Scand J Clin Lab Invest, 2000;60(4) :299~309
  • 3Yoshimura M, Yasue H, Okumura K, et al. Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure. Circulation, 1993;87(2) :464~469
  • 4Friedl W, Mair J, Thomas S, et al. Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise. Clin Chim Acta, 1999;281(1 ~ 2):121~126
  • 5Maeda K, Tsutamoto T, Wada A, et al. Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end - diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J, 1998; 135(5 Pt 1) :825~832
  • 6Luchner A, Muders F, Dietl O, et al. Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction. Cardiovasc Res, 2001 Aug 15;51(3) :601~607
  • 7Bettencourt P, Ferreira A, Dias P, et al. Evaluation of brain natriuretic peptide in the diagnosis of heart failure. Cardiology, 2000; 93(1~2):19~ 25
  • 8Yamamoto K, Burnett JC Jr, Bermudes EA,et al. Clinical criteria and biochemical markers for the detection of systolic dysfunction. J Card Fail, 2000;6(3): 194 ~ 200
  • 9Dao Q, Krishnaswamy P, Kazanegra R, et al. Utility of B - type natriuretic peptide in the diagnosis of congestive heart failure in an ur gent - care setting. J Am Coll Cardiol,2001 ;37(2) :379~385
  • 10Kato M, Kinugawa T, Ogino K, et al. Augmented response in plasma brain natriuretic peptide to dynamic exercise in patients with left vens tricular dysfunction and congestive heart failure. J Intern Med, 2000;248(4):309~315

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