摘要
目的:探讨了小儿急性肾炎患者血清白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子(TNF)在急性肾炎发生、发展过程中的变化及相互关系。方法:用放射免疫分析检测了31例急性肾炎患儿血清中IL-2、IL-6、TNF水平,并以30例正常健康儿童作比较。结果:急性肾炎患儿血清中IL-6、TNF水平显著高于正常人组(P<0.01),而IL-2水平显著低于正常人组(P<0.01)。直线相关分析显示,IL-6、TNF水平与BUN呈正相关(P<0.01)。结论:血清IL-2、IL-6、TNF在小儿急性肾炎的发生、发展过程中相互作用,观察其浓度的变化对探讨其发病机理及指导用药均有重要临床价值。
Objective To investigate the changes of serum IL-2,IL-6 and TNF levels in pediatric patients with acute nephritis. Methods Serum IL-2,IL-6 and TNF levels were measured with RIA in 31 pediatric patients with acute nephritis and 30 controls. Results Serum levels of IL-6,TNF were significantly higher in patients with acute nephritis than those in controls (P<0.01), but serum IL-2 were significantly lower in the patients (P<0.01). Serum IL-6 and TNF levels were positively correlated to BUN levels (P<0.01). Conclusion These cytokines participated in the pathogenesis of acute nephritis in children. Mornitoring the changes of their serum levels was helpful for the management of the disease.
出处
《放射免疫学杂志》
CAS
2005年第3期188-189,共2页
Journal of Radioimmanology
