期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

酿酒酵母锌簇转录因子Pdr1和Pdr3的研究进展 被引量：1

Advances in the Study on Zinc Cluster Transcription Factors Pdr1 and Pdr3 in Saccharomyces cerevisiae
下载PDF
导出
摘要 Pdrl(pleiotropic drug-resistant 1)和Pdr3是酿酒酵母中锌簇转录因子,具有调控多种多药耐药转运蛋白的作用。它们主要以二聚体的形式与靶基因的PDREs(Pdrlp/Pdr3p response elements,PDREs)区域结合,对多药耐药靶基因进行调控,从而引起酿酒酵母对环己亚胺、寡霉素等药物的耐药现象。Pdr3的表达调控还受到线粒体基因组的影响。 Pdr1 and Pdr3 are zinc cluster transcription factors in Saccharomyces cerevisiae. They bind with PDREs of the target genes as homodimers or heterodimers, and in the presence of the activation domains they can regulate several transporter proteins correlated with pleiotropic drug resistance. In addition, mitochondrion genome in yeast can regulate the expression of Pdr3.
作者 王德俊 徐铮 曹永兵 姜远英
机构地区 第二军医大学药学院药理学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2005年第3期217-219,共3页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.30300442)~~
关键词 锌簇转录因子 Pdr1 Pdr3 酿酒酵母 zinc cluster transcription factors Pdrl Pdr3 Saccharomyces cerevisiae
分类号 Q933 [生物学—微生物学]
  • 相关文献

参考文献20

  • 1Balzi E,Chen W,Ulaszewski S, et al.The multidrug resistance gene PDR1 from Saccharomyces cerevisiae.J Biol Chem, 1987, 262(35): 16 871-9.
  • 2Delaveau T, Delahodde A, Carvajal E, et al.PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon.Mol Gen Genet, 1994, 244(5):501-11.
  • 3Vallee BL, Coleman JE, Auld DS.Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.Proc Natl Acad Sci USA.1991,88(3):999-1 003.
  • 4Mamnun YM, Pandjaitan R, Mahe Y, et al.The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo- and heterodimers in vivo.Mol Microbiol, 2002, 46(5):1 429-40.
  • 5Akache B, MacPherson S, Sylvain M, et al.Complex interplay among regulators of drug resistance genes in S.cerevisiae.J Biol Chem, 2004, 279(27):27 855-60.
  • 6Hellauer K, Akache B, MacPherson S, et al.Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter.J Biol Chem, 2002, 277(20): 17 671-6.
  • 7Simonics T, Kozovska Z, Michalkova-Papajova D, et al.Is-olation and molecular characterization of the carboxy-terminal pdr3 mutants in Saccharomyces cerevisiae.Curr Genet, 2000, 38:248-55.
  • 8Kolaczkowska A, Kolaczkowski M, Delahodde A, et al.F-unctional dissection of Pdr1p, a regulator of multidrug resistance in Saccharomyces cerevisiae.Mol Genet Genomics, 2002, 267: 96-106.
  • 9DeRisi J, van den Hazel B, Marc P, et al.Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett, 2000, 470:156-60.
  • 10Onda M, Ota K, Chiba T, et al.Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors: involvement of Pdr3 in salt tolerance.Gene,2004,12,332:51-9.

同被引文献9

  • 1Pfaller MA. Antifungal drug resistance:mechanisms, epidemiology, and consequences for treatment [J]. Am J Meal, 2012, 125 ( I Suppl) : S3 -13.
  • 2Vale - Silva L, lscher F, Leibundgut - Landmann S, et al. Gain - of - function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells [J].Infect lmmun, 2013,81 (5) :1709 - 1720.
  • 3Goffa E, Bialkova A, Batova M, et al. A yeast cell - based system for screening Candida glabrata multidrug resistance reversal agents mad selec- tion of loss - of- function pdrl mutants[J]. FEMS Yeast Res, 2011 , 11 (2) :155 - 159.
  • 4Ferrari S, Sanguinetti M, Torelli R, et al. Contribution of CgPDRI - regulated genes in enhanced virulence of azole - resistant Candida glabrata [J]. PLoS One, 2011,6(3) :e17589.
  • 5Edlind TD, Henry KW, Vermitsky JP, et al. Promoter - dependent dis- ruption of genes:simple, rapid, and specific PCR- based method with ap- plication to three different yeast [J]. Curt Genet, 2005,48 (2):117 - 125.
  • 6Scherer S, Davis R W. Replacement of chromosome segments with al- tered DNA sequences constructed in vitro [ J ]. Proc. Natl. Acad. Sea. USA, 1979,76(10) :4951 -4955.
  • 7Paul S, Schmidt JA, Moye - Rowley WS. Regulation of the CgPdrl transcription factor from the pathogen Candida glabrata [ J]. Eukaryot Cell, 2011,10 ( 2 ) : 187 - 197.
  • 8Song JW, Shin JH, Kee SJ, et aL Expression of CgCDRI, CgCDR2, and CgERGI 1 in Candida glabrata biofilms formed by bloodstream isolales [ J ]. Meal Mycol, 2009,47 ( 5 ) :545 - 548.
  • 9李樊,刘义,何钢.基因敲除技术研究进展[J].生物技术通报,2008,24(2):80-82. 被引量：14

引证文献1

二级引证文献1

医学分子生物学杂志
2005年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部