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CDH13基因的研究进展 被引量：5

Advances in the Study of CDH13 Gene
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摘要 CDH13是一个独特的钙粘蛋白。近来的研究表明,CDH 13是一个抑癌基因,此外,它在细胞粘附、信号转导及细胞生长调节等方面也发挥着重要作用。CDH 13表达的沉默可由其基因5’启动子区的异常甲基化或等位基因的缺失与异常甲基化的联合作用导致。 CDH13 is a unique cadherin. Recent studies have shown that CDH13 is a tumor suppressor gene. Moreover, CDH13 plays an important role in cell-cell interaction, signal transduction and cell growth regulation. The silencing of CDH13 expression is caused by aberrant methylation of 5' promoter region of the gene or a combination of allelic loss and aberrant methylation. In this article, we review the current advances in CDH13 research.
作者 孙昀 耿小平 朱立新
机构地区 安徽医科大学附属第一医院肝胆外科
出处 《医学分子生物学杂志》 CAS CSCD 2005年第3期224-226,共3页 Journal of Medical Molecular Biology
关键词 CDH 13 抑癌基因 甲基化 CDH13 tumor suppressor gene methylation
分类号 Q786 [生物学—分子生物学]
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参考文献28

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同被引文献59

  • 1冯景,张吉才,陶建蜀,吕军,付萍,郭建华,周有利.散发性乳腺癌患者血浆BRCA1基因启动子异常甲基化的检测[J].中国癌症杂志,2005,15(5):442-445. 被引量：14
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引证文献5

二级引证文献9

医学分子生物学杂志
2005年 第3期

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