摘要
目的评价化疗联合后程加速超分割放射治疗食管癌的疗效。方法70例食管癌患者,随机分为2组,化放组36例,单纯放疗组34例。放疗采用60Coγ线外照射,先前一后二野等中心照射40Gy后改用后程加速超分割放疗,(2次/d,1.5Gy/次),全疗程总剂量共67-70Gy,化疗采用5-FU+CF+DDP。结果化放组与单放组1、3、5年生存率分别为71.0%、51.6%、29.1%和48.1%、30.0%、10.2%,两组对比差异有显著性(P<0.05)结论化疗加后程加速超分割治疗食管癌能提高生存率,患者容易耐受。
Objective To evaluate the effect of chemotherapy plus late course hyperfractionated accelerated radiotherapy (LCHART) for esophageal carcinoma. Methods Seventy patients with esophageal carcinoma were randomized into two groups. Thirty six patients received chemotherapy plus radiotherapy(CT-RT) , 34 received radiotherapy(RT). All patients were firstly given with y-ray, total tumor dose was 40Gy/20F, with conventional fractionation regimen and followed by 1. 5Gy LCHART, twice daily. The total dose varied up to 67-70Gy, chemotherapy regimen was FD(5-Fu,CF and DDP). Results One-, three-and five-year survival rate in CT-RT group and RT group were 71. 0% ,51. 6% ,29.1 % and 48. 1 % ,30. 0% , 10. 2% respectively (P <0. 05). Conclusion Chemotherapy plus LCHART can increase the survival rate in patients with esophageal carcinoma.
出处
《肿瘤》
CAS
CSCD
北大核心
2005年第3期289-290,共2页
Tumor
关键词
食管肿瘤
药物疗法
放射疗法
综合疗法
Esophageal neoplasms
Drug therapy
Radiotherapy
Combined modality therapy
