摘要
背景与目的:从遗传学角度评价山茱萸果肉醇提物的潜在危害性,为山茱萸开发为保健功能性食品提供科学依据。材料与方法:采用小鼠睾丸染色体畸变试验,小鼠骨髓微核实验以及小鼠精子畸形实验方法。结果:山萸肉醇提物诱发小鼠睾丸染色体畸变实验,诱发小鼠精子畸形实验以及微核实验结果显示,各剂量组与阴性对照相比较,差异均无显著性。结论:山萸肉醇提液对实验动物均没有染色体与细胞水平上的损伤作用,结合其它毒理学资料可以考虑作为新食品资源利用。
BACKGROUND&AIM: To check the mutagenicity of the matter extracted from the Pulp of cornus by ethanol. MATERIAL AND METHODS: Chromosome aberration test,micronucleus test of bone marrow cell and sperm shape abnormality test in mice were used in this study. RESULTS: The test result shows that:there have no significant difference between the matter extracted from the pulp of cornus by ethanol and negative control,but has significant difference to positive control. CONCLUSION: The matters extracted has no damage effect on the chromosome and cell levels.It provides science proof on exploiting functional health food of cornus of ficinalis sieb.et Zucc.
出处
《癌变．畸变．突变》
CAS
CSCD
2005年第3期187-189,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
山萸肉
醇提液
致突变
pulp of cornus
the matter extracted by ethanol
mutagenicity
