摘要
目的探讨血压正常高值人群大动脉顺应性的变化。方法选择年龄相似血压正常的健康者及没有任何靶器官损害的Ⅰ～Ⅱ级高血压患者191例,分为3组:正常血压组64人;正常高值组75人;高血压组52人。应用脉搏波速度(PWV)测定仪对所有入选者进行同时测定颈动脉桡动脉(CRPWV),颈动脉股动脉的脉搏波速度(CFPWV),及血压、身高、体重、体重指数(BMI)、腰围、臀围、腰臀围比值、心率(HR)等。结果CFPWV、CRPWV在正常组(8.9±1.6)m/s和(8.8±1.1)m/s、血压正常高值组(9.7±1.6)m/s和(9.7±1.4)m/s,高血压组3组中分别为(10.0±1.4)m/s和(10.3±1.5)m/s。方差分析示,3组间各因素比较除年龄、心率外均存在统计学差异。两组间的SNK检验示:血压正常高值组的身高、体重、BMI、腰臀围比值,CRPWV及CFPWV均大于正常组,P<0.05;而年龄、脉压(PP)、心率无统计学差异,P>0.05。正常高值组与高血压组的比较,CRPWV有明显的统计学差异,P<0.05。血压正常的健康人(血压正常高值组和理想血压组)的PWV与各因素的简单相关(Pearson)分析示:CRPWV与收缩压(SBP)、舒张压(DBP)、身高、HR相关;CFPWV与年龄、SBP、PP、BMI相关。CFPWV、CRPWV多因素逐步线性回归分析示:CFPWV与年龄、SBP、身高、体重关系密切;CRPWV与DBP、HR紧密相关。结论1、血压正常高值患者已经存在动脉顺应性的减退;2、血压正常人群的动脉顺应性随年龄、血压、HR的增高而减退。
ObjectiveTo investigate the changes of compliance in large arteries in prehypertensive people.Methods 191 subjects with no obvious target organ damage were allocated into 3 groups, normotensive(n=64), prehypertensive (n=25) and hypertensive patients(n=52).Age, SBP, DBP, PP, HR, height, BMI, and waist/hip ratio were measured.ResultsThe mean C-FPWV and C-RPWV in prehypertensives group(9.7±1.5 and 9.7±1.4)m/s was greater than that of normotensives[(8.9±1.6 and 8.8±1.1) m/s, P<0.05] and less than that of hypertensives[(10.0±1.4 and 10.3±1.8)m/s, P<0.05].One way ANOVA showed that all above variables but age and HR were significantly different among the 3 groups.Weight, height, BMI waist/hip ratio, C-RPWV, and C-FPWV in prehypertensive groups were greater than that of normotensive (all P<0.05). C-RPWV was correlated with SBP, DBP, height, and HR, while C-FPWV with age, SBP, PP and BMI.Multiple regression analysis showed that age, SBP, height, and weight were the main determinants for C-FPWV, while DBP and HR were closely related to C-RPWV.ConclusionPrehypertensive patients already had change of compliance in large arteries even no obvious target organ damage was found. Arterial compliance was decreased with the increase of age, blood pressure, heart rate in prehypertensive patients.
出处
《高血压杂志》
CSCD
北大核心
2005年第5期273-276,共4页
Chinese Journal of Hypertension
