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生物样品中双膦酸类药物的分析 被引量：3

The Analysis of Bisphosphonates in Biological Samples
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摘要 双膦酸类药物(bisphosphonates)是一类抗代谢性骨骼疾病的药物，包括双膦酸和双膦酸盐，其基本结构见图1。该类药物主要用于治疗骨质疏松症、变形性骨炎、恶性肿瘤引起的高钙血症和骨痛症等，双膦酸类药物副作用小，毒性低，但在治疗过程中也会产生诸如消化道反应和抑制骨质矿化等副反应。通过检测生物样品中的双膦酸药物浓度，可为药代动力学研究、生物利用度研究、治疗药物监测及保证用药的安全性和有效性提供有效手段，因此建立灵敏可靠的用于生物样品中双膦酸类药物分析的方法很有必要。
作者 蒋晔 谢赞 张晓青
机构地区 河北医科大学药学院
出处 《药物分析杂志》 CAS CSCD 北大核心 2005年第5期597-601,共5页 Chinese Journal of Pharmaceutical Analysis
关键词 双膦酸类药物 生物样品 药代动力学研究 生物利用度研究 治疗药物监测 骨质疏松症 变形性骨炎 药物副作用 消化道反应 骨骼疾病 双膦酸盐 高钙血症 恶性肿瘤 治疗过程 药物浓度 药物分析 代谢性 毒性低 副反应 安全性
分类号 R917 [医药卫生—药物分析学] R115 [医药卫生—公共卫生与预防医学]
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参考文献35

  • 1黄海英.双膦酸盐类药物研究及应用进展[J].中国药房,2002,13(4):247-248. 被引量：8
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二级参考文献14

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药物分析杂志
2005年 第5期

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