摘要
采用放射免疫法对１６例终末期肾衰（ＥＳＲＦ）患者血浆精氨酸加压素（ＡＶＰ）、心钠素（ＡＮＰ）水平进行观察。研究发现ＥＳＲＦ患者血浆ＡＶＰ和ＡＮＰ水平明显增高。血透后血压正常组病例ＡＶＰ降至正常，但高血压组血浆ＡＶＰ水平逐渐升高，且与血钠浓度升高密切相关，可能与该组患者对钠浓度改变处于高敏状态有关。透析后两组患者血浆ＡＮＰ水平明显下降，并与超滤脱水有关。因此，测定ＡＶＰ，ＡＮＰ水平可作为推测透析患者体内水、钠负荷状态，制定个体化透析的灵敏指标。
he changes of the plasma AVP andANP in 16 patients with
end-stage renalfailure (ESRF) in hernodialysis were deter-mined by rneans of specific
radioim-munoassay. The results showed that thelevels of plasma AVP and ANP in the pa-tients
with ESRF were significantly elevat-ed. After hemodialysis, the level of plasmaAVP in the cases
of normal blood pressurefell to the normal level ,but the level of plas-ma AVP in the cases of
high blood pressurewas gradually elevated and was closely cor-related with the elevation of
plasma Na+concentration (r = 0. 63, P < 0. 05). Thismight be related to the patients'
hyperreac-tive condition in response to the changes ofNa+ concentration. After hemodialysis
thelevels of plasma ANP in two groups of pa-tients decreased significantly ( P< 0.01),itseemed
to be closely correlated with ultrafil-tration volume. We believe that the loss ofANP from
hemodialysis fluid is not themain reason of the decrease of its blood con-centration, although
ANP could passhemodialysis mernbrane.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1994年第5期376-378,共3页
Chinese Journal of Nephrology,Dialysis & Transplantation
