摘要
【目的】探讨丹参素对豚鼠心室肌细胞钠电流的影响。【方法】采用全细胞膜片钳技术,记录了不同豚鼠的24个心室肌细胞的给药前后不同时间段的Na+内向电流。【结果】丹参素25μmol/L组和50μmol/L对豚鼠心室肌细胞Na+通道电流均具有明显的抑制作用,并呈剂量依赖性。【结论】丹参素减少Na+通道电流的作用,可能为其抗心肌缺血的作用机制之一。
ObjectiveTo study the effects of Danshensu on the sodium current. MethodsThe endocurrent of twenty-four isolated ventricular cells of guinea-pig in different time quantums was analyzed by the whole cell voltage clamp technique.ResultsDanshensu (25, 50 μmol/L) showed inhibition to the sodium current in a dose-dependent manner.ConclusionThese results indicate that inhibition of Danshensu to the sodium current may be one of mechanisms of its myocardial antiischemia action.
出处
《武警医学院学报》
CAS
2005年第4期256-257,263,共3页
Acta Academiae Medicinae CPAPF
