摘要
应用硼氢化钠还原法合成三个硒代鬼臼毒素衍生物。合成过程温和,无毒害,产率较高。通过红外吸收谱图、核磁谱图和质谱分析与目标产物一致。对卵巢癌细胞H O-8910具有一定的细胞毒作用,并与化合物浓度呈明显正相关。
Three derivatives of selenoylpodophyllotoxin were composed with the reduce method. The synthetic process is temperate; no toxicity and high rate of output. Derivatives are the same with target product through IR, 1HNMR, 13CNMR and EI-MS. Three derivatives have in vitro cytotoxicity on HO-8910 cell, and the cyto-toxicity is positively related to the monomer concentration.
出处
《天水师范学院学报》
2005年第2期42-44,共3页
Journal of Tianshui Normal University
