期刊文献+

外周T细胞TCR基因的重排(编辑/修正)与选择 被引量:9

下载PDF
导出
摘要 T细胞在胸腺发育过程中,TCR通过VDJC基因重排(rearrangement)和选择(细胞水平选择或克隆选择,cellorclonalselection),而组成了外周多样性的T细胞库。现证实外周的T细胞存在着TCR的第二次重排(编辑/修正,editing/revision)与选择(受体水平或分子水平的选择,receptorormolecularselection),即外周的T细胞能重新开放RAG酶等进行VDJC基因的重新编排,修正原来的TCR或产生全新的TCR,再一次选择成为产生耐受或特异应答的新的T细胞,这种机制在外周T细胞库的扩展、自身免疫病、T细胞的外周耐受、肿瘤和感染、免疫缺陷和移植等免疫应答机制中发挥重要作用。
出处 《现代免疫学》 CAS CSCD 北大核心 2005年第3期256-258,262,共4页 Current Immunology
基金 国家973资助项目(2001CB510008 2003CB514113)广东省自然科学基金资助项目(010613)
  • 相关文献

参考文献21

  • 1Kouskoff V, Nemazee D. Role of receptor editing and revision in shaping the B and T lymphocyte repertoire[J]. Life Sci, 2001,69 (10):1105-1113.
  • 2Serra P, Amrani A, Han B, et al. RAG-dependent peripheral T cell receptor diversification in CD8^+ T lymphocytes[J]. Proc Natl Acad Sci USA, 2002,99(24):15566-15571.
  • 3Buch T, Rieux-Laucat F, Forster I, et al. Failure of HY-specific thymocytes to escape negative selection by receptor editing [J].Immunity, 2002,16(5):707-718.
  • 4Cooper CJ, Orr MT, McMahan C J, et al. T cell receptor revision does not solely target recent thymic emigrants [J]. J Immunol,2003,171(1):226-233.
  • 5Shockett PE, Zhou S, Hong X, et al. Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes[J].Mol Immunol, 2004,40(11):813-829.
  • 6Ye P, Kirschner DE. Measuring emigration of human thymocytes by T-cell receptor excision circles[J]. Crit Rev Immunol, 2002,22 (5-6):483-497.
  • 7Kondo E, Wakao H, Koseki H, et al. Expression of recombination-activating gene in mature peripheral T cells in Peyer′s patch[J]. Int Immunol, 2003,15(3):393-402.
  • 8Bas A, Sten G. Extrathymic TCR gene rearrangement in human small intestine: identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression[J]. J Immunol, 2003,171:3359-3371.
  • 9Li TI, Han S, Cubbage M, et al. Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells[J]. Eur J Immunol, 2002,32(10):2792-2799.
  • 10Ali M, Weinreich M, Balcaitis S, et al. Differential regulation of peripheral CD4^+ T cell tolerance induced by deletion and TCR revision[J]. J Immunol, 2003,171(11):6290-6296.

共引文献5

同被引文献96

引证文献9

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部