摘要
目的探讨氯沙坦对犬在体心肌缺血再灌注时心肌损伤的保护作用。方法16只健康家犬,分为2组:(1)对照组(n=8),阻断左前降支主干30min后恢复前降支血流30min。应用单相动作电位记录技术,同步记录犬在体心肌再灌注时单相动作电位及体表心电图;(2)氯沙坦组(n=8):氯沙坦5mg/(kg·d)经胃管灌入,持续2周后开胸,缺血再灌注方法及观察指标同对照组。结果再灌注30min内,对照组8只犬中有5只出现了早期后除极(EAD)和再灌注室性心律失常,再灌注心律失常发生率为62.5%;氯沙坦组3只犬出现EAD和再灌注室性心律失常(37.5%,P<0.05),氯沙坦组EAD和心律失常发生率较对照组明显减小(P<0.01)。结论氯沙坦可抑制再灌注时EAD的发生,可能因此而减少再灌注心律失常的发生。
Objective To evaluate the protective effect of losartan, an angiotensin II type 1 (AT1) receptor antagonist, against myocardial ischemic reperfusion in intact canine. Methods Sixteen dogs were divided into model group(n=8) with left anterior descending coronary artery occlusion for 30 min followed by reperfusion for 30 min and losartan group (n=8) with 5 mg/(kg·d) intragastric losartan administration for 2 weeks before the ischemic-reperfusion model establishment. Monophasic action potential recording technique was employed to observe the incidence of early after depolarization (EAD) and reperfusion arrhythmias. Results In the model group, 5 dogs (62.5%) developed EAD and reperfusion arrhythmia while 3 (37.5%) developed the symptoms in losartan group, showing significant difference between the two groups (P<0.05). No ventricular tachycardia or ventricular fibrillation was observed in losartan group (P<0.01). Conclusion Losartan can suppress the occurrence of EAD during reperfusion following myocardial ischemia to reduce the incidence of reperfusion arrhythmias, suggesting its protective effect against myocardial ischemic injury.
出处
《第一军医大学学报》
CSCD
北大核心
2005年第5期580-581,共2页
Journal of First Military Medical University
关键词
再灌注心律失常
氯沙坦
早期后除极
monophasic action potential
ischemic reperfusion
losartan
early after depolarization
