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炎性细胞因子在脑出血继发性脑损害中的作用 被引量：11

The Role of Inflammatory Cytokines in Secondary Brain Injury Following Intracerebral Hemorrhage
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摘要 脑出血急性期血肿及其周围组织炎症反应在继发性脑损害中起重要作用。多种炎性细胞因子表达增加,其中IL1、IL6、IL8、肿瘤坏死因子α和干扰素γ主要促进水肿和炎症反应,而黏附分子则是它们发挥作用的分子基础。 Inflammatory response in inflammatory response in and around the hematoma following intracerebral hemorrhage play an important part in secondary brain injury. The expression of kinds of inflammatory cytokines increased. Among them, IL-1, IL-6, IL-8, tumor necrosis factor-α and interferon-γ mainly promote edema and inflammatory response, while cell adhension molecules play the role of their molecular basis.
作者 吴万福 胡长林
机构地区 重庆医科大学附属第二医院神经内科
出处 《国外医学（脑血管疾病分册）》 2005年第4期303-306,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 继发性脑损害 炎性细胞因子 肿瘤坏死因子-α 脑出血急性期 细胞因子表达 炎症反应 干扰素-γ 周围组织 IL-1 IL-6 IL-8 分子基础 发挥作用 黏附分子 intracerebral hemorrhage ■ inflammatory cytokines ■ secondary brain injury
分类号 R743.34 [医药卫生—神经病学与精神病学]
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参考文献25

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  • 2Lopez-Cortes LF, Marquez-Arbizu R, Jimenez-Jimenez LM, et al.Cerebrospinal fluid tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-8 as diagnostic markers of cerebrospinal fluid infection in neurosurgical patients. Crit Care Med, 2000, 28:215 -219.
  • 3Fassbender K, Rossol S, Kammer T, et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci, 1994, 122:135 - 139.
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  • 7Taupin V, Toulmond S, Serrano A, et al. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of preand post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol, 1993,42:177 - 185.
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国外医学（脑血管疾病分册）
2005年 第4期

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