摘要
目的探讨大剂量肾上腺糖皮质激素冲击治疗重度颅脑损伤。方法按GCS分级,把159例重度颅脑损伤随机分为两组,大剂量激素冲击治疗重度颅脑损伤80例为治疗组,没有用激素者79例为对照组。治疗组根据病情,每天用甲基强地松龙1000～3000mg,连用3～5d,对两组病患者的并发症、生命体征、GCS评分进行对比。结果显示两组之间的差异有显著意义(P<0.05)。结论大剂量肾上腺糖皮质激素冲击治疗重度颅脑损伤可明显减轻脑水肿,减少并发症,提高生存率。
Objective To investigate the function of large dosage of the corticosteroids in the impact curing the heavy brain hunting.Methods According GCS classification,the heavy degree brain hunting is random divided into two groups.Using the large dosage of hormone to impact cure the heavy degree brain hunting as the treatment set,did not use the hormone of patients for the contract group.According to the sufferers' state of the illness,use the Methylprednisolone 1000～3000mg everyday,connect to use 3～5 days.To compare with the complication,life sign,the course of disease and disease transform,for two groups of patients.Results Having the obvious difference form the two groups(P<0.05).Conclusion The corticosteroids have the function of alleviating hydrocephalus,reducing complication,restraining the inflammation gene and other harmful gene releasing.And protecting the cell membrane's stability,strengthen the tissue to suffer from bearing of lacking oxygen.The side effect is little.
出处
《中国基层医药》
CAS
2005年第5期571-572,共2页
Chinese Journal of Primary Medicine and Pharmacy
