摘要
目的研究肝移植术后感染的革兰氏阴性杆菌的病原菌及其药敏特征。方法采用KB法检测肝移植术后感染革兰氏阴性杆菌的药敏情况,双纸片确证法、三维试验检测肠杆菌的超广谱β内酰胺酶(ESBLs)、AmpC酶产酶情况。结果55例肝移植术后感染的病原菌中革兰氏阴性杆菌占47.6%,对4种及4种以上抗生素的耐药率均超过40%,阴沟肠杆菌与大肠杆菌的产ESBLs与产AmpC酶检出率分别为32.4%、36.8%和38.8%、10.5%。结论肝移植术后以革兰氏阴性杆菌感染为主,对抗生素具有高耐药性与多重耐药性特点,产ESBLs与产AmpC酶是主要革兰氏阴性杆菌产生耐药性的重要因素,应引起临床的高度重视。
Objective To study the infectious pathogens of Gram-Negative bacillus and their characteristic of antibiotic susceptibility after liver transplantation.methods The susceptibility of antimicrobial agents of the infectious Gram-Negative bacillus was detected by K-B method after liver transplantation.Extended-spectrum beta-lactamases(ESBLs)and Ampc β-lactamases were detected by disk diffusion method and three-dimensional tests respectively.Results Among 55 cases of the infection after liver transplantation the rate of Gram-Negative bacillus to the total pathogens was 47.6%. and the rate of drug-resistance to four or more antibiotic exceeded (40.0%),32.4%,while 36.8% produced ESBLs among Enterobacter cloacae and Escherichia coli,(33.8%) and 10.5% produced Ampc β-lactamases.Conclusion Gram-Negative bacillus may be the majority of the pathogens in the patients receiving liver transplantation, which have the chatacterestic of multiple drug-resistance.Producing ESBLs and Ampcβ-lactamases are the primary factor of antibiotic resistance of Gram-Negative bacillus.We should pay much attention to it during clinical process.
出处
《江西医学院学报》
2005年第3期17-19,共3页
Acta Academiae Medicinae Jiangxi
关键词
肝移植
感染
革兰氏阴性杆菌
耐药性
liver transplantation
infection
gram-negative bacillus
drugtolerance
