摘要
目的构建大鼠糖尿病溃疡动物模型,观察评价该模型的临床及病理特点。方法利用磁片循环压迫的方法,构建大鼠糖尿病溃疡动物模型,并从整体,组织和生化三个层次对糖尿病溃疡进行了研究。结果构建出了一个可以复制的糖尿病溃疡动物模型,该模型具有组织坏死、白细胞聚集以及高浓度晚期糖化终末产物等特征。结论利用缺血再灌注法构建了大鼠糖尿病溃疡动物模型。其病理改变与人极为相似,是一种很好的用于糖尿病溃疡发病机制和治疗研究的动物模型。
Objective To establish a reproducible rat model of chronic diabetic ulcers and investigate their characteristics and major pathological features. Methods\ The rat model of chronic diabetic ulceration was induced by repeated cyclic magnetic compression on the skin. The skin injury was measured grossly and tissue samples were taken for histological examination and biochemical assay. Results\ The model generates reproducible skin injury as characterized by tissue necrosis, leukocytes inflitration and high concentration of advanced glycation endproducts (AGEs). Conclusion\ A rat model of diabetic ulcers was established by an ischemia reperfusion method. The models present virtually all the pathological characteristics found in human diabetic ulcers. Therefore, it is a useful animal model in investigation of pathogenesis and therapy of diabetic ulcers.
出处
《中国实验动物学报》
CAS
CSCD
2005年第2期88-90,F010,共4页
Acta Laboratorium Animalis Scientia Sinica
