摘要
目的:探讨短期应用他汀类药物后脑梗死患者血清C反应蛋白及血脂水平的变化,并了解其应用的安全性。方法:采用随机、双盲、安慰剂对照的方法进行研究,将2004-02/07大连医科大学附属第一医院收治的46例脑梗死患者分为对照组及他汀组(辛伐他汀40mg/d或阿托伐他汀20mg/d,连续用药7d)。对照组采用曲克芦丁、阿司匹林、维生素C等药物治疗。治疗前后检测血清C反应蛋白、血脂、血清谷草转氨酶及血清肌酸激酶水平。结果:46例均进入结果分析。他汀组C反应蛋白水平(中位数)治疗前为3.25mg/L,治疗后为2.00mg/L,治疗前后差值(-1.00mg/L)与对照组(0.70mg/L)相比有显著差别(P<0.01)。他汀组的总胆固醇、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇水平(中位数)治疗前为4.88,1.29及2.80mmol/L,治疗后为3.60,0.99及2.13mmol/L,治疗后血脂水平较对照组显著下降(P均<0.01)。治疗后各组谷草转氨酶及肌酸激酶水平无明显变化。治疗过程中各组均无梗死后出血的病例。结论:短期应用他汀类药物可以降低脑梗死患者血清C反应蛋白及血脂水平,安全性好。
AIM:To study the changes in the levels of serum C reactive protein and blood lipids in patients with cerebral infarction after shortterm treatment of statins,and study its reliability. METHODS:Totally 46 cerebral infarction patients selected from the First Affiliated Hospital of Dalian Medical University,from February to July 2004,were divided into control group(administration of violaquercitrin,aspirin, vitamin C,etc.) and statins group(40 mg of simvastatin or 20 mg of atorvastatin per day for 7 days),and were studied by using a randomized,doubleblind,and placebocontrolled method.The levels of C reactive protein,blood lipids,aspartate aminotransferase and creatine kinase were detected before and after treatment. RESULTS:All the 46 cases were involved in the study.The median of serum C reactive protein levels in statins group was 3.25 mg/L before treatment,and 2.00 mg/L after treatment.The change of serum CRP levels in statins group(-1.00 mg/L) was significantly different from that in control group(0.70 mg/L)(P< 0.01).The levels(median) of serum total cholesterol,highdensity lipoprotein cholesterol and lowdensity lipoprotein cholesterol in statins group were 4.88 mmol/L,1.29 mmol/L and 2.80 mmol/L before treatment,and 3.60 mmol/L,0.99 mmol/L and 2.13 mmol/L after treatment.The serum lipids levels in statins group after treatment decreased significantly as compared with those in control group(P< 0.01).The levels of aspartate aminotransferase and creatine kinase had no changes after treatment.Postinfarction hemorrhage did not occur during the treatment. CONCLUSION:Shortterm treatment of statins can safely reduce the levels of serum C reactive protein and blood lipids in patients with cerebral infarction.
出处
《中国临床康复》
CSCD
北大核心
2005年第21期114-116,共3页
Chinese Journal of Clinical Rehabilitation
