摘要
本文比较了鼠尾藻醇提取物（ＳＴ１，ＳＴ２，ＳＴ３）体外抑制人食管癌细胞株（ＥＣ１０９）的生理活性。结果表明，浓度为２５～１００ｍｇ／ｍｌ不同浓度的提取物作用４８ｈ后均出现明显抑制。用５％浓度的ＳＴ１～３连续１０天腹腔注射分别对小鼠肉瘤Ｓ１８０有３４．５％（ｐ＞０．０５），５５％（ｐ＜０．０５）和５０％（ｐ＜０．０１）的抑制率。实验发现，ＳＴ１和ＳＴ３对荷瘤鼠血浆Ａ／Ｇ比值有显著影响。ＳＴ１对菏瘤鼠压积红细胞ＳＯＤ活性较对照组低３０％。ＳＴ１可刺激人粒细胞超氧阴离子自由基（Ｏ２－）的释放，表明ＳＴ２对粒细胞有激活作用。
comparative study was made on the
inhibition effect of the alcohol extracts(ST1,ST2,ST3)from Sargassum thunhesgii on human
esophageal cancer cell stain (109)in vitro. The results showed that esophageal cancer growth
was obviously inhibited by all the three of alcohol extracts at concentration of 25～
100mg/ml.Intraperitoneal injection of 5%ST1～3 solutions for 10 days decreased the growth of
S180 by 34.5%(P>0.05),55%(P<0.05)and 50%(P<0.01)respectively.The extracts ST1 and ST3
had a distinct effect on the bloOd plasma A/G ratio,increasting the globulin concentration of
blood plasma by 22～26%.THe extract ST1 had some effect on the superoxide dismutase of
the compacted deposits of red cells,decreasing it by 30%. Low concentration ST2 increase
releasing from granulo-cytes.The results showed that the granulocyes were activated by ST2.
出处
《药物生物技术》
CAS
CSCD
1994年第1期30-34,共5页
Pharmaceutical Biotechnology
基金
广东省高等教育局资助课题
关键词
鼠尾藻
醇提取物
生理活性
肿瘤
药物疗法
Sargassum thunbergii
Alcohol extracts
Physiological Activity
