摘要
从糙皮侧耳真菌（Ｐ．Ｏｓｔｒｅａｔｔｕｓｆｕｎｇ）中提取出糖肽（Ｐ．ＯｓｔｒｅａｔｕｓＧｌｙｃｏｐｅｐｔｉｄｅｓ，ＰＯＧＰ）。体内、外实验表明，ＰＯＧＰ有促进ＬＡＫ和ＮＫ细胞杀伤瘤细胞的作用；药理实验显示有抑制小鼠Ｓ１８０瘤细胞增殖和向周围组织侵袭的作用；病理检测可见ＰＯＧＰ能引起瘤组织坏死，淋巴细胞浸润，并形成较厚的纤维包膜。提示ＰＯＧＰ具有使肿瘤组织纤维化的作用。
ne of glycopeptides,named POGP,was extracted from P.
Ostreatus fungi.In vitro ,vivo, POGPcould enhance the activitv of LAKcelss a nd N K cells to t
umor cells.It could inhibit the infiItration oftumor cells into surrounding normal tissues、as well
as the proliferation of S180 cells.In pathologicalstudy,POGP could lead to death of tumor
tisstue,infiltration by lymph cells and formation of fibroin-tegument with certain thickness. THe
results suggested that POGP may be used to stimulate the in-crease of fiber in tumor tissue.
出处
《药物生物技术》
CAS
CSCD
1994年第1期35-38,共4页
Pharmaceutical Biotechnology
关键词
糙皮侧耳真菌
糖肽类
LAK细胞
肿瘤
免疫学
Pleurotus Ostreatus Fungi
glycopeptides
LAK cell
natural kill
cell
immunocompe-tence: antitumor action
