摘要
结果显示，实验８周末对照组动物全部形成肝硬化，肝胶原蛋白含量升高，纤维连接蛋白及层粘连蛋白量从２周起逐渐增加，８周末最明显，结蛋白阳性细胞２至６周增加，８周末减少，显示已转变为成纤维细胞。经丹参治疗的动物无一只发生肝硬化，肝内胶原蛋白含量，纤维连接蛋白及层粘连蛋白含量均明显低于对照组，结蛋白阳性细胞２至６周低而８周末高于对照组，提示丹参可减轻实验性肝硬化动物细胞外基质的产生，并减少贮脂细胞转化为成纤维细胞。
The results Indicated that
all the rats in control group developed cirrhosis accompanied with
increment of hepatic collagen after injection CCI4 and dietetic
injury for 8 weeks. Fibronectin and laminin contents in liver were
increased gradually,but desmin positive cells were increased from 2
to 6 weeks,decreased after 8 weeks which indicated that DM+2 cells
transformed to fibroblasts. There was no rat developed cirrhosis in
SM trent- ing group. The contents of hepatic collagen,FN and LN were
lower significantly in SM group compared with controls. DM+ cells
were lower from 2 to6 weeks, but it was higher than controls after 8
weeks. The results indicated that SM could decrease the contents of
extracellular matrix and DM+ cells transfoming fibroblasts in
experimental cirrhosis.
