摘要
目的:探讨凋亡抑制蛋白Survivin和转移抑制蛋白nm23在乳腺癌组织中的表达及与腋淋巴结转移和5年生存率的关系。方法:用免疫组织化学SP法检测80例乳腺癌组织中Survivin,nm23的表达,分析其与腋淋巴结转移和5年无病生存率之间的关系。结果:Survivin蛋白在乳腺癌中阳性表达率为68.75%(55/80),与腋淋巴结转移呈低度正相关(r=0.263,P=0.019),与5年无病生存率呈低度负相关(r=-0.255,P=0.024);nm23阳性表达率为57.50%(46/80),与腋淋巴结转移呈低度负相关(r=-0.253,P=0.024),与5年无病生存率低度正相关(r=0.235,P=0.037)。Survivin和nm23蛋白表达与肿瘤病理类型、发病年龄、临床分期无明显相关性(P>0.05)。结论:Survivin蛋白的抑制凋亡作用和nm23蛋白的抑制转移作用可能在乳腺癌的发生、发展过程中起重要作用,联合检测有助于判断乳腺癌的预后。
Objective To investigate the expressions of Survivin protein and nm23 protein and the relationship among the expressions and axillary lymph node metastasis in breast cancer. Methods The expression of Survivin and nm23 in 80 cases of breast cancer tissues were detected by immunohistochemistry SP method, and their correlation with axillary lymph node metastasis and 5-year disease free survival (DFS) were analysed. Results Survivin protein positive expression rate was 68.75%(55/80) in breast cancer tissues, which had positive correlation with the axillary lymph nodes metastasis but negative correlation with 5 years FS(P<0.05); nm23 protein expression had negative correlation with the axillary lymph nodes metastasis but positive to 5 years FS(P<0.05). Survivin and nm23 proteins expression had no obvious correlation with the breast cancer pathology type, patient age and clinical stage(P>0.05). Conclusion The anti-apoptosis effect of Survivin protein and the anti-metastasis effect of nm23 protein may be important in the occurrence and advancement of breast cancer, suggesting that it may be a new indicator of prognostic and judgement in breast cancer.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2005年第3期312-314,334,共4页
Journal of Central South University ：Medical Science
