摘要
本文应用c-myc癌基因蛋白和增殖细胞核抗原(PCNA)免疫组织化学方法,研究了它们在正常大肠粘膜、结肠炎、腺瘤和腺癌中的表达。发现结肠炎和肿瘤c-myc蛋白和PCNA阳性率较正常粘膜高。在管状腺瘤、管状绒毛状腺瘤和绒毛状腺瘤,阳性率呈进行性增加,但没有统计学意义。c-myc蛋白和PCNA表达呈相关性。肿瘤中阳性细胞呈异质性,所以要得到可靠的研究结果应多点取材。
Two monoclonal antibodies, anti-c-myc protein and proliferating cell nuclear antigen (PCNA), were used in an immunohistoche-mical reaction to examine the colonic epithelium in normal mucosa, colitis, adenoma and carcinoma. In colitis and tumors the proportion of c-myc protein and PCNA-positive epithelial cells was higher than in normal. There exists a trend that the positive rates of c-myc protein and PCNA are progressively higher in the sequence of tubular, tubovillous and villous adenomas, al-though not significant (Pc-myc = 0. 5293, PPCNA = 0. 5450). There is a good correlation between c-myc protein and PCNA expression. The distribution of positive cells in the tumor is heteroge-nous, so more biopsies in a tumor must be studied to obtain reliable results of the tumor prolif-erative kinetics.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1994年第1期7-10,T001,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
C-MYC蛋白
增殖细胞核
大肠肿瘤
c-myc protein
proliferating cell nuclear antigen
colitis
colon adenoma
colon carcinoma
