摘要
运用免疫组织化学方法对化学致癌剂诱发的大鼠原发性肝细胞性肝癌细胞及前胃鳞状细胞癌的增殖细胞核抗原（ＰＣＮＡ）及表皮生长因子受体（ＥＧＦγ）的表达进行了仔细的观察，结果表明：上述两种因子在两种癌细胞中均呈阳性免疫反应。依癌巢周围肥大细胞（ＭＣ）数的多少，将其分为两组：具丰富ＭＣ浸润组与缺乏ＭＣ浸润组。运用统计学方法，分别对两组癌巢中ＰＣＮＡ阳性细胞进行计数，结果：缺乏ＭＣ浸润组ＰＣＮＡ阳性细胞数远高于具丰富ＭＣ浸润组，二者之比在肝癌约为３：１，在前胃癌为２：１。ＥＧＦｒ在两组肿瘤中均呈过度表达，但缺乏ＭＣ浸润组的ＥＧＦｒ阳性细胞数明显高于ＭＣ丰富组。两种因子显示结果基本一致。
he expression of PCNA and EGFy in chemically induced hepatocellular carcinoma and souamous cell carcinoma cells from rats were observed with immunohistochemical techniques. The results showed that the carcinoma cells of both tumors revealed a positive immunoreaction to both factors. According to the amount of MC surrounding the tumor cell nests,the specimens could be divided into two groups:the group with abundant MC infiItration and the group with little or no MC infiItration. The PCNA positive cells in carcinoma cell nests of both groups were calculated respectively. It revealed that the amount of PCNA positive cells in the group with little or no MC was significantly more than that in the other group.The ratio between the 2 groups in liver carcinoma was approxirnately 3:1 and in stomach cancer it was 2:1.Anoverexpression of EGFY was observed in tumor tissues of both groups, but the amount of EGFγ positive cells in the group with little or no MC was much higher than that of the group with abundant MC.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1994年第5期274-277,T056,共5页
Chinese Journal of Pathology
基金
国家自然科学基金
关键词
肝肿瘤
胃肿瘤
表皮生长因子
抗原
Liver neoplasms Stomachneoplasms Receptors,epidermal growth factor-urogastrone Proliferating cell nuclear antigen
