摘要
将４０只大鼠带蒂胃壁瓣分别自体移植到十二指肠、空肠及结肠，于术后３、６、９、１２个月，分批处死动物进行观察。胃粘膜由胃内酸性环境进入肠道碱性环境后，发生了广泛肠化生，化生组织内含有杯状细胞、柱状细胞及潘氏细胞，部分标本中有肠型隐窝形成。十二指肠和空肠移植的胃壁瓣粘膜显示碱性磷酸酶阳性肠化生。透射电镜和扫描电镜观察可见杯状细胞和典型或非典型微绒毛。研究结果证实了胃粘膜肠上皮化生是一种微环境相关性变化，似乎相对较高的ｐＨ值能诱发胃粘膜肠化生。
he pedicled gastric wall flaps of Wistar
rats weretransplanted to their duodenum, Jejunum and colonrespectively. After the operation the
rats were killed atthe 3th, 6th, 9th and 12th month respectively.Intestinal metaplasia (IM) was
observed in all the gas-tric grafts transplanted to the intestines underphotomicroscope, TEM
and SEM . Alkalinephosphatase positive IM was seen in the gastric graftmucosa transplanted to
the duodenum and jejunum.The results showed that the formation of IM of thegastric mucosa
may be related to a change of themicroenvironment around the tissues and that gastricmucosa
may differentiate into intestinal mucosa by theincrease of pH value.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1994年第3期147-149,T017,共4页
National Medical Journal of China
基金
全军八五重点攻关项目
关键词
胃粘膜
化生
移植术
Gastric mucosa
MetaplasiaTransplant Animal, laboratory
