摘要
目的:为完善感冒灵颗粒的质量控制方法。方法:采用薄层鉴别和高效液相色谱法,增订了咖啡因、野菊花的薄层鉴别,修订了对乙酰氨基酚的含量测定。结果:通过方法学考察,对乙酰氨基酚的进样量在0.1441μg^1.1532μg范围内,呈良好的线性关系。对乙酰氨基酚的平均回收率(n=5)为99.80%,RSD为0.25%。结论:薄层鉴别,方法专属、斑点清晰;含量测定方法,简便、灵敏、重现性好、精密度高。可有效控制感冒灵颗粒剂的质量。
Objective:To Consummate a method for the quality control of Ganmao Ling Granules.Method:Identification of Caffeine and Flos Chrysanthemi Indici were revised by TLC.The content of paracetamol in Ganmao Ling Granules was determined by HPLC.Results:The methodological study showed that a good linear correlation existed in the range of 0.1441μg to 1.1532μg of the paracetamol applied.The average recovery of paracetamol(n=5)was 99.8% and RSD was 0.25%.Conclusion:The method of TLC was exclusive and spots were clear.The method for content determination is simple,accurate and with good repeatability and high precision.The method can be used for quality control of Ganmao Ling Granules.
出处
《中国药品标准》
CAS
2005年第3期32-35,共4页
Drug Standards of China
