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死亡受体、配体系统与卵巢肿瘤 被引量:3

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摘要 细胞凋亡主要表现为凋亡信号通路的启动及相关基因的表达,不同信号转导途径介导和参与细胞凋亡的发生过程,其中死亡受体信号途径是直接启动凋亡的一条最具特征性的路径。细胞表面死亡受体是肿瘤坏死因子受体超家族成员,死亡受体信号通过与其特异性配体结合,以其独特的诱导凋亡方式参与细胞凋亡的过程,介导肿瘤细胞凋亡。卵巢肿瘤的发生除了与多种癌基因和抑癌基因的异常激活和表达有关以外,细胞凋亡的抑制也是其形成的重要机制。就死亡受体、配体系统的有关机制及其与卵巢肿瘤的关系做一综述。
出处 《国外医学(计划生育分册)》 2005年第4期208-212,共5页
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