摘要
目的探讨胃癌组织中生存素(survivin)的表达及其与各临床病理因素的关系,评价生存素在胃癌预后判断中的价值。方法应用免疫组织化学Elivision法检测了102例胃癌组织中生存素的表达,回顾性分析生存素与各临床病理因素及预后之间的关系。结果胃癌组织中生存素表达阳性率为52.9%(54/102)。淋巴结转移阳性胃癌的生存素表达阳性率66.7%(32/48)明显高于淋巴结转移阴性胃癌的阳性表达率37%(20/54)(P<0.05);TNM分期Ⅰ、Ⅱ期的胃癌生存素表达阳性率54.3%(38/70)与TNM分期Ⅲ、Ⅳ期者62.5%(20/32)差异不明显(P>0.05);分化较差的胃癌生存素表达阳性率65.5%(19/29)与分化较好者47.9%(35/73)差异不明显(P>0.05)。此外生存素表达阳性率在肿瘤部位、浸润深度、肿瘤大小等方面差异不明显。生存期<2年的患者胃癌组织中生存素表达阳性率68.6%(35/51)明显高于生存期>5年患者的阳性表达率37.3%(19/51)(P<0.01)。结论生存素在胃癌组织中具有较高的表达率,其表达与胃癌的淋巴结转移相关。生存素的表达状态是胃癌根治术后独立的预后因素,阳性表达提示预后不良。
Objective To investigate the relationship between the expression of survivin and the clinical pathologic parameters in gastric carcinoma,and evaluate its significience in predicting the prognosis.Methods Immunohistonchemical method by Elivision was used to detect survivin expression in 102 patients with gastric carcinoma.The relationship between survivin expression and the clinical pathologic parameters,and prognosis was retrospectively analyzed.Results Survivin expresion was positive in 54 of 102 cases(52.9%).The positive expression rate in cases with lymphoid metastasis was significantly higher than that without.No significant defference in positive expression rate was found between TNM stage,histological grade.The positive expression rate was significantly higher in cases living less than 2 years than that longer than 5 years(68.6% vs 37.3%,P<0.05).Conclusions Upregutated expression of survivin can be found in patients with gastric carcinoma.Survivin expression is significantly correlated with lymphoid metastasis.Survivin is an independent predictor for the patients with gastric carcinoma after radical resection.
出处
《江苏医药》
CAS
CSCD
北大核心
2005年第7期494-495,共2页
Jiangsu Medical Journal
