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肝纤Ⅰ号冲剂对慢性病毒性肝炎肝纤维化的临床疗效的影响 被引量:3

Clinical Study of Ganxian Granules Ⅰ for the Treatment of Liver Fibrosis Induced by Chronic Virus Hepatitis
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摘要 [目的]观察肝纤Ⅰ号冲剂对慢性病毒性肝炎肝纤维化的临床疗效的影响。[方法]采用数字表法将200例慢性病毒性肝炎肝纤维化病例,随机分为治疗组120例及对照组80例,在护肝、对症处理及无活血化瘀中药治疗的基础上,治疗组服用肝纤Ⅰ号冲剂(由汉防己、桃仁、三七等组成),每次1袋(10g),每天3次;对照组服用大黄(?)虫丸,每次9g,每天3次。治疗2个疗程(半年)后,观察两组的临床综合疗效,比较两组治疗前后肝功能各项指标及血清中透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)等肝纤三项的含量变化,同时观察两组B超检查结果及肝组织病理学改善情况。[结果]治疗组总有效率为87.5%,明显优于对照组的70.0%(P<0.05)。在降低肝纤维化指标HA、LN、PCⅢ方面,治疗组疗效均优于对照组(与对照组比较P<0.05)。治疗组在改善脾脏厚度方面疗效优于对照组,有显著性差异(P<0.05),但对门静脉宽度的影响两组无显著性差异(P>0.05)。治疗组各项肝功能指标的改善均优于对照组(P<0.05),且具有良好的安全性。[结论]肝纤Ⅰ号冲剂治疗慢性病毒性肝炎肝纤维化患者,可有效降低肝纤维化程度和改善各项肝功能指标,疗效确切且服用安全。 [Objective] To observe the therapeutic effect of Ganxian Granules Ⅰ (mainly composed of Radix Stephani-ae Tetrandrae, Semen Persicae and Radix Notoginseng) for the treatment of liver fibrosis induced by chronic virus hepatitis. [Methods] Two hundred cases of liver fibrosis induced by chronic virus hepatitis were randomized into group A (n = 120) and group B ( n = 80). Group A received Ganxian Granules Ⅰ 10g per day, tid, and group B received Dahuang Zhechong Pills 9g per day, tid for half a year. The therapeutic effect in the two groups was evaluated after treatment. The changes of hepatic function and serum levels of hyaluronidase (HA) , laminin (LN) and type Ⅲ precolla-gen ( PC Ⅲ) were compared before and after treatment. Meanwhile, type B ultrasonographic results and hepatic pathologic features were observed. [Results] The total therapeutic effective rate was 87.5% in group A, higher than 70.0% in group B ( P < 0.05) . Serum levels of HA, LN and PC Ⅲ were decreased and the spleen thickness was also reduced in group A ( P < 0.05 compared with group B). However, the effect on the width of portal vein in group A did not differ from that in group B (P > 0.05). Group A had a better effect in improving the hepatic function than group B (P < 0.05), and Ganxian Granules Ⅰ was safe during the treatment. [ Conclusion ] Being effective and safe, Ganxian Granules Ⅰ can reduce the fibrosis degree and improve hepatic function in treating liver fibrosis induced by chronic virus hepatitis.
作者 左俊岭
出处 《广州中医药大学学报》 CAS 2005年第4期259-262,共4页 Journal of Guangzhou University of Traditional Chinese Medicine
关键词 肝炎 慢性/中药疗法 肝硬化/中药疗法 肝纤Ⅰ号冲剂/治疗应用 活血祛瘀 HEPATITIS, CHRONIC/TCD therapy LIVER CIRRHOSIS/TCD therapy GANXIAN GRANULES Ⅰ/therapeutic use ACTIVATING BLOOD AND REMOVING STASIS
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