摘要
目的观察葛根素对家兔心肌缺血再灌注损伤的保护效果。方法20只兔随机分为生理盐水组(A组)、葛根素治疗组(B组)。采用放免法检测血清超氧化物岐化酶(SOD)、血浆心钠素(ANF)。结果与A组比较,B组血清SOD活性、血浆ANF含量明显增高(P<0.01)。结论葛根素可明显减轻家兔心肌缺血再灌注损伤。
Objective To observe the protective effects of Puerarin on rabbit myocardial ischemia-reperfusion injury. Methods The model of myocardial ischemia reperfusion injury in rabbits were established,twenty rabbits were divided randomly into two groups:group A given 0.85%sodium chloride treatment before ischemia-reperfusion,and group B given Puerarin before ischemia-reperfusion contents of serum superoxide dismutase and plasma atrial natriuretic factor were observed by radioimmunoassay method. Results Compared with group A ,puerarin can significantly increased serum superoxide dismutase and plasma atrial natriuretic factor level(P<0.01). Conclusion Puerarin can reduce myocardial ischemia reperfusion injury in rabbits.
出处
《青海医学院学报》
CAS
2005年第2期102-104,共3页
Journal of Qinghai Medical College
关键词
葛根素
心肌缺血再灌注损伤
SOD
ANF
Puerarin Myocardial ischemia reperfusion injury Superoxide dismutase Atrial natriuretic factor
