摘要
建立了毛细管GC法同时测定紫杉醇中丙酮、乙酸乙酯、甲醇和二氯甲烷4种有机溶剂残留量。采用HP-INNOWax毛细管柱,内标乙腈。4种有机溶剂的线性范围分别为47～141、50～150、47～141、30～90μg/ml,平均回收率分别为102.2%、93%、99.8%、96.4%。
A capillary GC method was established for determination of residual organic solvents——acetone,ethyl acetate, methanol and dichloromethane in paclitaxel. A HP-INNOWax capillary column was used with acetonitrile asthe internal standard. The calibration curve of four solvents were linear in the ranges of 47 - 141, 50 - 150, 47 - 141 and30 - 90μg/ml, respectively. The average recoveries were 102.2%, 93%, 99.8% and 96.4%, respectively.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第7期420-421,共2页
Chinese Journal of Pharmaceuticals
