摘要
探讨中药消痔灵注射液对肝肿瘤的治疗价值和毒副作用。将SD大鼠35只,分为5组,经肝动脉注射不同剂量消痔灵注射液,观察大鼠生存情况。另取SD大鼠39只,建立Walker256肝脏移植瘤模型,分为3组,分别经肝动脉注射生理盐水、阿霉素碘油乳剂、消痔灵注射液,比较治疗后肝内肿瘤体积大小的变化及各组荷瘤大鼠的生存期。结果:消痔灵注射液较大剂量可使肝脏大片状坏死,影响生存;而5mg/kg剂量组大鼠可长期生存,肝脏肉眼无明显变化。治疗后肿瘤体积比较,阿霉素碘油组、消痔灵液组体积均明显减小,与生理盐水组比较有显著性差异(P<0.01)。在生存期方面,消痔灵液组平均生存期高达(47.67±9.22)d,与生理盐水组和阿霉素碘油组比较与有显著性差异(P<0.01)。结论:合适剂量的消痔灵注射液经肝动脉灌注对大鼠移植性肝肿瘤有一定的抑制作用,能够延长荷瘤大鼠的生存期。
This paper studied the clinical efficacy and side effects of “Xiaozhiling Injection” in treating liver tumor. Thirty-five rats were randomized into five groups and treated by different does of the Injection and their survival conditions were observed. Another 39 rats were modeled to be of liver transplantation tumor and then randomly divided into three groups that were respectively treated by normal saline, Adriamycin and “Xiaozhiling Injection” through hepatic artery perfusion; the size of liver tumor and the survival period were observed. Results: Large dose of “Xiaozhiling Injection” could cause liver necrosis and affect survival; 5 mg/kg of “Xiaozhiling Injection” could not affect the survival and liver tissue; the tumor reduced in Adriamycin group and “Xiaozhiling Injection” group, with significant difference in comparison with normal group, P<0.01; the average survival period was (47.67 +9.22) days in “Xiaozhiling Injection” grooup, shorter than those in normal and Adriamycin groups, P<0.01. It is concluded that “Xiaozhiling Injection” can suppress the tumor growth and delay the survival period of tumor-bearing rats.
出处
《上海中医药杂志》
北大核心
2005年第7期48-49,共2页
Shanghai Journal of Traditional Chinese Medicine
基金
上海中医药大学科研基金资助(0136)
关键词
消痔灵注射液
肝肿瘤
经肝动脉化疗栓塞术
疗效
毒副作用
“Xiaozhiling Injection”
liver tumor
chemotherapeutic embolism through hepatic artery
side effect
