摘要
目的对喜树碱类药物的一些特殊传递系统进行综述。方法通过文献检索,以脂质体、微球、聚合物载体等新型的传递系统为主,介绍近几年喜树碱类药物传递系统的研究进展。结果通过一些特殊的传递方法与策略,可以解决喜树碱类药物所存在的溶解度、稳定性、毒性和不良反应等问题。结论随着新的药物传递系统的不断成熟与发展,喜树碱类药物将是十分有潜力的一类抗肿瘤药物。
Objective To review some delivery systems for camptothecin and its analogs in recent years.Method Liposome,polymer carrier,microsphere and other delivery systems for camptothecin were reviewed in detail.Result The problems of camptothecin such as solubility,stability and side effects could be solved by special delivery methods and strategies.Conclusion As the development and maturation of some novel drug delivery system,camptothecin will be a kind of potential anticancer drugs.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2005年第4期315-320,共6页
Journal of Shenyang Pharmaceutical University
基金
国家新药研究基金项目(949720)
辽宁省教育厅重大项目计划(202043233)
