摘要
在4种自制的涂敷型纤维素衍生物手性柱,即纤维素三苯甲酸酯(CTB)、纤维素三(4甲基苯甲酸酯)(CTMB)、纤维素三苯基氨基甲酸酯(CTPC)和纤维素三(3,5二甲基苯基氨基甲酸酯)(CDMPC)与小分子的Prikle型(S,S)WhelkO1手性柱上对取代环己酮及取代环己醇进行了对映体分离。研究了溶质的立体结构因素对手性分离的影响,并初步探讨、比较了溶质在这两种手性柱上的手性识别的机理。结果发现,在(S,S)WhelkO1柱上溶质与固定相之间的吸引作用是手性识别的主要原因,而对于纤维素衍生物手性柱,溶质的空间结构在手性空腔中的空间适应性可能是手性识别的关键。
This paper reported the chiral separation of substituted cyclohexanone and substituted cyclohexanol using self-prepared cellulose derivative CTB, CTMB, CTPC, CDMPC whose structures were shown in Fig. 2 of the text and (S, S)-Whelk-O 1 columns. The influence of the structures of the analytes on the chiral separation was studied. The difference of chiral recognition mechanism on cellulose derivative chiral columns and (S, S) -Whelk-O 1 columns was compared. The results indicate that on (S, S) -Whelk-O 1 the attraction between solute and stationary phase is primary to the chiral recognition, while on cellulose derivative chiral columns the solutes' stereo structure must play a chief role in meeting the requirement for a stereoseletive fit into the cellulose chiral cavity, which may be the key to the chiral recognition on cellulose derivatives chiral stationary phase.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2005年第7期965-968,共4页
Chinese Journal of Analytical Chemistry
基金
浙江省科技计划(No.2004C33050)
分析测试基金(No.03111)资助项目
