摘要
目的研究中国人群中IL-1B-511位点单核苷酸多态性(singlenucleotidepolymorphism,SNP)与侵袭性牙周炎(aggressiveperiodontitis,AgP)之间的关系。方法提取122名AgP患者和95名健康对照者外周静脉血基因组DNA,应用聚合酶链反应-限制性片段长度多态性的方法,分析IL-1B-511位点SNP与AgP的关联性。结果男性AgP组杂合基因型的频率较男性健康对照组升高并有统计学意义(P=0·048);A2+基因型/等位基因A2与吸烟联合作用显著增加了AgP的易感性(基因型:P=0·022;等位基因:P=0·006)。结论IL-1B-511位点的SNP可能与中国人群中男性个体的AgP易感性有关;该位点的SNP与吸烟可能对AgP的易感性具有联合效应。
Objectives:To study whether Interleukin-1B (IL-1B) -511 genotype and/or allele were associated with aggressive periodontitis (AgP) in Chinese.Methods: AgP group consisted of 122 patients and healthy controls group consisted of 95 subjects. Single nucleotide polymorphism at IL-1B -511 was analyzed by standard Polymerase Chain Reaction-Restriction Fragment Length Polymorphism assay. Results: The frequency of IL-1B -511 A1/A2 heterozygote was significantly increased in male AgP group compared to male control (P = 0.048). The adjusted OR of AgP for combined A2+ genotype and smoking was 12.45 (P = 0.022), and for combined allele 2 and smoking was 18.25 (P = 0.006).Conclusion: The IL-1B -511 polymorphism may play an important role in determining AgP susceptibility in Chinese male. A possible combined effect of the IL-1B -511 polymorphism and smoking on AgP susceptibility was suggested.
出处
《中国优生与遗传杂志》
2005年第7期22-24,共3页
Chinese Journal of Birth Health & Heredity
基金
国家自然科学基金(基金编号:#30271411)
教育部教育振兴行动计划特殊专项("九八五"工程)(基金编号:北京大学人类疾病基因研究中心2001-8)
国家高科技项目(863计划)(基金编号:2002AA21701)
关键词
牙周炎
多态性
白细胞介素1
疾病遗传易感性
Periodontitis
Polymorphism
Interleukin-1
Genetic predisposition to disease
