摘要
目的评价小剂量芬太尼持续滴注对机械通气早产儿的镇痛作用、神经行为以及短期预后的影响。方法2000年10月至2003年10月,将广东省妇幼保健院新生儿科行机械通气治疗的36例早产儿随机分为实验组与对照组,实验组18例早产儿滴注芬太尼,平均剂量为(1.10±0.06)μg/(kg·h),平均滴注时间为(65±5)h,对照组18例患儿,以相同滴注速度滴注注射用水。应用镇静行为评分评价患儿的镇静效果,并记录各患儿的通气指标以及预后数据。结果实验组的镇静行为评分显著低于对照组,2组的机械通气参数及短期预后无显著差异。结论短时间小剂量滴注芬太尼可降低机械通气的早产儿行为评分,并能取得良好的镇痛效果。
Objective To evaluate the effects of low dose fentanyl infusion analgesia on behavioural and neuroendocrine stress response and short term outcome in ventilated preterm infants.Methods From Oct.2000 to 2003,18 ventilated preterm infants were randomly assigned to receive a mean fentanyl infusion of (1.1±0.06)μg/(kg·h) for (65±5) hours,and 18 untreated infants were considered as the control group.A behavioural sedation score was used to assess the infants' behaviour.Outcome data and ventilatory indexes were recorded for each infant.Results The fentanyl group showed significantly lower behavioural stress scores than controls.The two groups showed no significant difference in ventilatory variables or short term outcome.Conclusion A short course of low dose fentanyl infusion reduces behavioural sedation scores and neuroendocrine stress response in preterm ventilated infants.
出处
《中国实用儿科杂志》
CSCD
北大核心
2005年第7期427-428,共2页
Chinese Journal of Practical Pediatrics
关键词
芬太尼
肺透明膜病
疼痛刺激
机械通气
Fentanyl Pulmonary hyaline membrane disease Stress response Mechanical ventilation