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血管紧张素转换酶基因多态性与心血管疾病关系的研究进展 被引量：4

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摘要 目的血管紧张素转换酶(angiotensincomvertingenzyme,ACE)第16内含子存在一段287碱基对的插入(Insertion,I)和缺失(Deletion,D)多态。研究表明这一多态在一定程度上决定了ACE的血浆水平和生物活性进而通过。肾素血管紧张素系统(rininangiotensinsystem,RAS)对血管紧张素Ⅱ的生物活性和血浆水平产生影响,并使具有血管保护作用的缓激肽降解速度明显加快,从而跟高血压、冠心病、冠脉介入术后再狭窄等心血管疾病相关。但是目前该领域的研究的结果不尽相同,有的甚至完全相悖。表明其研究工作尚需不断完善和规范。
作者 王士强 吴延庆
机构地区 江西医学院研究生部 江西医学院第二附属医院心内科
出处 《实用临床医学（江西）》 CAS 2005年第7期141-143,146,共4页 Practical Clinical Medicine
关键词 血管紧张素转换酶 插入多态 缺失多态 心血管疾病
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献28

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共引文献41

同被引文献31

  • 1施珍,方宁远.白大衣高血压研究进展[J].心血管病学进展,2005,26(1):8-11. 被引量：18
  • 2刘长云,周建光,黄亚莉,方以群.血管紧张素转换酶基因多态性与高血压的关系[J].中华航海医学与高气压医学杂志,2006,13(5):290-291. 被引量：5
  • 3刘长云,周建光,施云星,李永平,吕礁.白大衣高血压患者的24h动态血压特征(附80例对照分析)[J].心血管康复医学杂志,2006,15(6):530-532. 被引量：3
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引证文献4

二级引证文献10

实用临床医学（江西）
2005年 第7期

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