摘要
目的探讨颈髓软化扩散张量成像的可行性及临床应用价值。方法采用平面回波成像技术对12例颈髓软化患者和36例健康志愿者行扩散张量成像(DTI)检查,并测量其表观扩散系数(ADC)值、各向异性分数(FA)值、第1本征值(λ1)、第2本征值(λ2)以及第3本征值(λ3)。结果ADC图与FA图均能显示颈髓软化区之异常信号,其ADC值为(1512.44±450.16)×10-6mm2/s,FA值为(407.81±86.14)×10-3,λ1值为(2229.31±417.19)×10-6mm2/s,λ2值为(1416.01±379.05)×10-6mm2/s,λ3值为(1401.48±589.18)×10-6mm2/s,2λ1/(λ2+λ3)值为1.67±0.23。颈髓软化患者病变区的ADC、λ1、λ2、λ3值明显高于正常组(P<0.05),其FA值与2λ1/(λ2+λ3)值明显低于正常组(P<0.05),λ1与λ2、λ3值之间有显著性差异(P<0.05),λ1大于λ2与λ3。结论DTI是一种显示颈髓软化的可靠检查手段,软化灶的各向同性扩散明显增高,其各向异性扩散明显减低。
Objective To investigate the feasibility and clinical application of MR diffusion tensor imaging (DTI) in myelomalacia of the cervical spinal cord. Methods DTI of the cervical spinal cord was performed in 12 cases of myelomalacia and 36 healthy volunteers by using SE-EPI. The values of apparent diffusion coefficient (ADC), fractional anisotropy (FA), λ_1, λ_2, and λ_3 were measured. Results Both ADC and FA maps were able to show abnormal signal intensities of myelomalacia. The average values of ADC, FA, λ_1, λ_2, λ_3, and 2λ_1/(λ_2+λ_3) were (1512.44±450.16)×10 -6 mm2/s, (407.81± 86.14 )×10 -3 , (2229.31±417.19)×10 -6 mm2/s, (1416.01±379.05)×10 -6 mm2/s, (1401.48±589.18)×10 -6 mm2/s, and 1.67±0.23, respectively. The values of ADC, λ_1, λ_2, and λ_3 of the myelomalacia increased evidently compared with those of normal cervical spinal cord (P<0.05), and the values of FA and 2λ_1/(λ_2+λ_3) decreased significantly compared with those of the control group (P<0.05). λ_1 was significantly higher than λ_2 or λ_3 (P<0.05). Conclusion DTI is a reliable tool in demonstrating the myelomalacia of the cervical spinal cord, and myelomalacia has a markedly increased isotropic diffusion and evidently decreased anisotropic diffusion.
出处
《中国医学影像技术》
CSCD
北大核心
2005年第7期1003-1005,共3页
Chinese Journal of Medical Imaging Technology
关键词
脊髓疾病
磁共振成像
扩散
平面回波成像
Spinal cord diseases
Magnetic resonance imaging
Diffusion
Echo-planar imaging
