摘要
从肿瘤化学治疗角度出发，检测维甲酸第二代低毒性衍生物维胺酸（ＲⅡ）作用于人鼻咽癌细胞母系ＣＮＥ－２Ｚ及其不同侵袭转移潜能的亚系Ｌ２、Ｈ２、Ｌ４细胞后，与肿瘤细胞恶性行为密切相关的一些生物学特性的变化。结果表明，ＲⅡ对人鼻咽癌细胞的体外生长和侵袭行为具有一定的抑制作用，并具有一定的诱导分化作用，提示ＲⅡ在抑癌抗癌方面很可能具有一定的应用前景。
N(4-hydroxycarbophenyl)retinamide(R Ⅱ)is a new synthetic analog of retinoids with low toxicty.Its effect on the biological properties associated with tumor malignant behavior of human nasopharyngeal carcinoma cell lines(HNCs),including CNE-2Z parentcell lines and their variants L2,H2,L4 was studied.RⅡ(10-5 mol/L)caused detectable morphologic differentiation of HNCs.It inhibited growth of HNCs in vitro and decreased ability of these cells to penetrate matrigel-coated filters by using a reconstituted basement membrane invasion assay.These results suggested that RⅡ might be a kind of useful anticancer drug.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1995年第5期353-358,共6页
Acta Academiae Medicinae Sinicae
基金
国家"八五"攻关课题
