摘要
晚期糖基化终末产物(AGEs)是蛋白质、脂质或核酸等大分子物质的非酶糖基化产物。其在体内有多种不同的存在形式,研究最多的是羧甲基赖氨酸(CML),它是AGEs的主要抗原表位,体内分布广泛,在糖尿病并发症等病变和衰老的发生、发展中有重要作用。
Advanced glycation end products(AGEs) are formed in proteins, lipids or RNAse by combined nonenzymatic glycation and oxidation(glycoxidation) reaction. AGEs are a heterogenous class of compounds,out of which the most important is N ε-(carboxymethyl)lysine,a major immunological epitope in advanced glycation end products,and plays an important role in the pathogenesis of numerous diseases, including diabetes complications,atherosclerosis and in the normal aging process.
出处
《东南大学学报（医学版）》
CAS
2005年第4期269-273,共5页
Journal of Southeast University(Medical Science Edition)
基金
国家自然科学基金资助项目(30070300)。
